Ashley Brower Niesman

Education

• Marymount Manhattan College, B.S., Biology, 2007

Positions

• 2023-present — Senior Research Associate and Lab Manager, Department of Biophysics, UT Southwestern Medical Center
• 2013-present — Senior Research Associate and Lab Manager, Department of Pharmacology, UT Southwestern Medical Center
• 2012-2013 — Research Assistant II and Lab Manager, Department of Pharmacology, UT Southwestern Medical Center
• 2008-2012 — Laboratory Supervisor, Marymount Manhattan College
• 2006-2007 — Research Intern, Memorial Sloan Kettering Cancer Center

Publications

1. Van Hauwenhuyse J, Reniers F, Persoons L, Noppen S, Wing CE, Niesman AB, Fung HYJF, Vanstreels E, Jacquemyn M, Boel E, Vankerckhoven A, Berckmans Y, Kwanten B, Coosemans A, Van den Mooter G, Chook YM, Dehaen W, Daelemans D. Preclinical characterization of a reversible XPO1 inhibitor for cancer therapy. Nat Commun. 2026.
2. McConville M, Lankford K, Bernardes NE, Walterscheid A, Valadez C, Niesman A, Chook YM, Liszczak G. Importin-9 recognizes the winged-helix fold of ETS transcription factors to mediate nuclear import. Proc Natl Acad Sci U S A. 2026 May 5;123(18):e2536763123.
3. Wing CE, Fung HYJ, Kwanten B, Cagatay T, Niesman AB, Jacquemyn M, Gharghabi M, Permentier B, Shakya B, Nandi R, Ready JM, Kashyap T, Shacham S, Landesman Y, Lapalombella R, Daelemans D, Chook YM. SINE compounds activate exportin 1 degradation through an allosteric mechanism. Nat Chem Biol. 2025 Dec;21(12):2002-2013.
4. Kariapper LS, Marathe IA, Niesman AB, Suino-Powell K, Chook YM, Wysocki VH, Worden EJ. Setdb1 and Atf7IP form a hetero-trimeric complex that blocks Setdb1 nuclear export. J Biol Chem. 2025 Jun;301(6):110171.
5. Fung HYJ, Mittal SR, Niesman AB, Jiou J, Shakya B, Yoshizawa T, Cansizoglu AE, Rout MP, Chook YM. Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5. Nat Commun. 2025 Mar 16;16(1):2580.
6. Fung HYJ, Jiou J, Niesman AB, Bernardes NE, Chook YM. Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus. J Cell Biol. 2025 Jan 6;224(1):e202408193.
7. Fung HYJ, Niesman A, Chook YM. An update to the CRM1 cargo/NES database NESdb. Mol Biol Cell. 2021 Mar 15;32(6):467-469.
8. Gonzalez A, Mannen T, Çağatay T, Fujiwara A, Matsumura H, Niesman AB, Brautigam CA, Chook YM, Yoshizawa T. Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X). Sci Rep. 2021 Feb 12;11(1):3754.
9. Volpon, L., Culjkovic-Kraljacic, B., Osborne, M. J., Ramteke, A., Sun, Q., Niesman, A., Chook, Y. M., & Borden, K. L. (2016). Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E. Proceedings of the National Academy of Sciences of the United States of America, 113(19), 5263–5268.

Contact

• Ashley.Brower@UTSouthwestern.edu
  214-645-6168